3-AMINO PYRROLIDINE HYDROCHLORIDE

Base Information

• Chemical Name: 3-AMINO PYRROLIDINE HYDROCHLORIDE
• CAS No.: 122458-34-8
• Molecular Formula: C₄H₁₀N₂*2ClH
• Molecular Weight: 159.059
• Hs Code.: 2933990090
• Mol file: 122458-34-8.mol

Synonyms:3-Pyrrolidinamine,monohydrochloride (9CI)

Chemical Property of 3-AMINO PYRROLIDINE HYDROCHLORIDE

Chemical Property:

• Refractive Index: ">
• Boiling Point: 171°Cat760mmHg
• Flash Point: 57.2°C
• PSA: 38.05000
• Density: g/cm³
• LogP: 1.13810
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%min ^*data from raw suppliers

Pyrrolidin-3-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO PYRROLIDINE HYDROCHLORIDE

There total 5 articles about 3-AMINO PYRROLIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

(R)-pyrrolidin-3-amine (116183-82-5) → (3R)-3-aminopyrrolidine dihydrochloride (103831-11-4,116183-81-4,116183-83-6,122458-34-8)

Guidance literature:

With hydrogenchloride; In ethanol; at 10 - 40 ℃;

Reference yield: 80.5%

(3R)-3-azido-1-(phenylmethyl)pyrrolidine (116143-03-4) → (3R)-3-aminopyrrolidine dihydrochloride (103831-11-4,116183-81-4,116183-83-6,122458-34-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 2.5h; under 760 Torr;

DOI:10.1021/jm00100a028

Reference yield:

(3S)-3-azido-1-(phenylmethyl)pyrrolidine (114636-29-2) → (S)-3-aminopyrrolidine dihydrochloride (103831-11-4,116183-81-4,116183-83-6,122458-34-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; for 2.5h; under 760 Torr;

DOI:10.1021/jm00100a028

upstream raw materials:

(3S)-3-azido-1-(phenylmethyl)pyrrolidine

(3R)-3-azido-1-(phenylmethyl)pyrrolidine

(R)-pyrrolidin-3-amine

Downstream raw materials:

7-((S)-3-Amino-pyrrolidin-1-yl)-6-fluoro-1-(4-fluoro-phenyl)-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

7-((S)-3-Amino-pyrrolidin-1-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-5-methyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester

(3S)-3-amino-1-(tert-butoxycarbonyl)-pyrrolidine

2-{[(3R)-3-aminopyrrolidin-1-yl]carbonyl}-3-[(2,4-difluorophenyl)amino]-7-phenylthieno[2,3-b]pyridin-6(7H)-one

Refernces

• 1、 Cesare, P. Di,Bouzard, D.,Essiz, M.,Jacquet, J. P.,Ledoussal, B.,et al.. "Fluoronaphthyridines and -quinolines as Antibacterial Agents. 5. Synthesis and Antimicrobial Activity of Chiral 1-tert-Butyl-6-fluoro-7-substituted-naphthyridones". . p. 4205 - 4213. Retrieved 2007/10/02.