methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate

Base Information

Chemical Name:methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate
CAS No.:955039-54-0
Molecular Formula:C₂₇H₂₃F₃N₂O₃
Molecular Weight:480.486
Hs Code.:

Synonyms:methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate

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Chemical Property of methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate

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Technology Process of methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate

There total 4 articles about methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1238214-74-8
1-[3-(trifluoromethyl)benzyl]-1H-indole-7-carboxylic acid

: methyl (S)-4-(1-aminoethyl)benzoate hydrochloride

: 955039-54-0
methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2010.04.065

Reference yield:

: 955039-52-8
methyl 1-[3-(trifluoromethyl)benzyl]-1H-indole-7-carboxylate

: 955039-54-0
methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / tetrahydrofuran; methanol / 50 °C

2: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 2 h / 0 - 20 °C

With sodium hydroxide; water; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; acetonitrile;

Reference yield:

: 93247-78-0
methyl 1H-indole-7-carboxylate

: 955039-54-0
methyl 4-{(1S)-1-[({1-[3-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]ethyl}benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C

2: sodium hydroxide; water / tetrahydrofuran; methanol / 50 °C

3: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 2 h / 0 - 20 °C

With sodium hydroxide; water; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;