[2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester

Base Information

Chemical Name:[2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester
CAS No.:801239-84-9
Molecular Formula:C₄₄H₆₂N₂O₉Si
Molecular Weight:791.07
Hs Code.:

[2-(3-{2-[2-(3-<i>tert</i>-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(<i>tert</i>-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1<i>H</i>-benzo[<i>c</i>]azepin-4-yl]-acetic acid methyl ester

Synonyms:[2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester

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Chemical Property of [2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester

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Technology Process of [2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester

There total 6 articles about [2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19614-12-1
2-bromo-5-methoxybenzyl bromide

: 801239-84-9
[2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: BBr₃ / CH₂Cl₂ / 2 h / -20 - 0 °C

2.1: 5.1 g / DMAP; iPr₂EtN / CH₂Cl₂ / 16 h / 0 °C

3.1: dimethylformamide / 20 °C

3.2: 1.8 g / aq. NaHCO₃ / diethyl ether / 0.25 h / 0 °C

4.1: 88 percent / tri-o-tolylphosphine; Pd(OAc)2; i-Pr₂EtN / various solvent(s) / 3 h / 90 °C

5.1: H₂; AcOH / Pd/C / ethanol / 48 h / 760 Torr

6.1: 1.5 g / i-PrEt₂N / xylene / 3 h / Heating

With dmap; palladium diacetate; N,N-diethyl-N-isopropylamine; hydrogen; boron tribromide; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; xylene; 4.1: Heck arylation;
DOI:10.1021/jm049666k

Reference yield:

: 54900-61-7
4-bromo-3-(bromomethyl)phenol

: 801239-84-9
[2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 5.1 g / DMAP; iPr₂EtN / CH₂Cl₂ / 16 h / 0 °C

2.1: dimethylformamide / 20 °C

2.2: 1.8 g / aq. NaHCO₃ / diethyl ether / 0.25 h / 0 °C

3.1: 88 percent / tri-o-tolylphosphine; Pd(OAc)2; i-Pr₂EtN / various solvent(s) / 3 h / 90 °C

4.1: H₂; AcOH / Pd/C / ethanol / 48 h / 760 Torr

5.1: 1.5 g / i-PrEt₂N / xylene / 3 h / Heating

With dmap; palladium diacetate; N,N-diethyl-N-isopropylamine; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; xylene; 3.1: Heck arylation;
DOI:10.1021/jm049666k

Reference yield:

: 801240-03-9
(4-bromo-3-bromomethyl-phenoxy)-tert-butyl-diphenyl-silane

: 801239-84-9
[2-(3-{2-[2-(3-tert-butoxycarbonylamino-propoxy)-ethoxy]-ethoxy}-propyl)-8-(tert-butyl-diphenyl-silanyloxy)-3-oxo-2,3,4,5-tetrahydro-1H-benzo[c]azepin-4-yl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethylformamide / 20 °C

1.2: 1.8 g / aq. NaHCO₃ / diethyl ether / 0.25 h / 0 °C

2.1: 88 percent / tri-o-tolylphosphine; Pd(OAc)2; i-Pr₂EtN / various solvent(s) / 3 h / 90 °C

3.1: H₂; AcOH / Pd/C / ethanol / 48 h / 760 Torr

4.1: 1.5 g / i-PrEt₂N / xylene / 3 h / Heating

With palladium diacetate; N,N-diethyl-N-isopropylamine; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; xylene; 2.1: Heck arylation;
DOI:10.1021/jm049666k