methyl N-crotyl-N-(α-methylbenzyl)malonylamide

Base Information

Chemical Name:methyl N-crotyl-N-(α-methylbenzyl)malonylamide
CAS No.:348620-14-4
Molecular Formula:C₁₆H₂₁NO₃
Molecular Weight:275.348
Hs Code.:

Synonyms:methyl N-crotyl-N-(α-methylbenzyl)malonylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl N-crotyl-N-(α-methylbenzyl)malonylamide

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Technology Process of methyl N-crotyl-N-(α-methylbenzyl)malonylamide

There total 1 articles about methyl N-crotyl-N-(α-methylbenzyl)malonylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 37517-81-0
3-chloro-3-oxopropanoic acid methyl ester

: N-crotyl-α-methylbenzylamine

: 348620-14-4
methyl N-crotyl-N-(α-methylbenzyl)malonylamide

Guidance literature:: With dmap; triethylamine; In ethyl acetate; at 0 - 20 ℃;
DOI:10.1021/jo001580l

Reference yield: 97.0%

: 348620-14-4
methyl N-crotyl-N-(α-methylbenzyl)malonylamide

: 243636-52-4
1-(α-methylbenzyl)-3-methoxycarbonyl-4-vinyl-2-pyrrolidinone

Guidance literature:: With copper diacetate; manganese triacetate; In acetic acid; at 20 ℃; for 18h;
DOI:10.1021/jo001580l

Reference yield:

: 348620-14-4
methyl N-crotyl-N-(α-methylbenzyl)malonylamide

: 126016-78-2
N-<4-<2-(2-amino-4,5,6,7-tetrahydro-4-oxo-3H-pyrrolo<2,3-d>pyrimidin-5-yl)ethyl>benzoyl>-L-glutamic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / Mn(OAc)3*2H₂O; Cu(OAc)2*H₂O / acetic acid / 18 h / 20 °C

2.1: 68 percent / P₄S₁₀ / tetrahydrofuran / 2.5 h / Heating

3.1: NaOMe / methanol / 0.5 h / 20 °C

3.2: 50 percent / methanol / 1 h / 90 °C / 15 Torr

4.1: 68 percent / Et₃N; CuI; (o-tolyl)3P / Pd(OAc)2 / dimethylformamide / 48 h / 75 °C

5.1: 6 percent / H₂ / Pd/C / methanol / 72 h / 50 °C / 2844.39 Torr

With copper(l) iodide; tetraphosphorus decasulfide; copper diacetate; hydrogen; sodium methylate; manganese triacetate; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; N,N-dimethyl-formamide; 4.1: Heck reaction;
DOI:10.1021/jo001580l