Technology Process of 4-(cyclohexylmethyl)-2,3-difluorobenzeneboronic acid
There total 3 articles about 4-(cyclohexylmethyl)-2,3-difluorobenzeneboronic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-(cyclohexylmethyl)-2,3-difluorobenzene;
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
With
Trimethyl borate;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1.5h;
With
hydrogenchloride;
In
tetrahydrofuran; hexane;
at 20 ℃;
Further stages.;
DOI:10.1021/jm070111+
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran
1.2: 36 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran
2.1: n-butyllithium; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: trimethyl borate / tetrahydrofuran; hexane / 1.5 h / -78 °C
2.3: 66 percent / aq. HCl / tetrahydrofuran; hexane / 20 °C
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; hexane;
DOI:10.1021/jm070111+
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran
1.2: 36 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran
2.1: n-butyllithium; N,N,N',N'-tetramethylethylenediamine / tetrahydrofuran; hexane / 1 h / -78 °C
2.2: trimethyl borate / tetrahydrofuran; hexane / 1.5 h / -78 °C
2.3: 66 percent / aq. HCl / tetrahydrofuran; hexane / 20 °C
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; hexane;
DOI:10.1021/jm070111+
