3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

Base Information

Chemical Name:3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide
CAS No.:1572517-04-4
Molecular Formula:C₁₉H₁₉N₃O₂S
Molecular Weight:353.445
Hs Code.:

Synonyms:3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

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Chemical Property of 3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

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Technology Process of 3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

There total 4 articles about 3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1572517-01-1
3-amino-N-(2-( 4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

: 1572517-04-4
3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

: 1572517-05-5
3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

Guidance literature:: With Lux Cellulose-3 (OJ) column; In methanol; diethylamine; Supercritical conditions;

Reference yield:

: 870244-34-1
3,5-dibromopyridine-4-carbonitrile

: 1572517-04-4
3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

: 1572517-05-5
3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / isopropyl alcohol / 1 h / 65 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 1 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3.1: water; potassium hydroxide / methanol / 9 h / 50 °C / Sealed tube

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

4.2: 1 h / 20 °C

5.1: Lux Cellulose-3 (OJ) column / methanol; diethylamine / Supercritical conditions

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; methanol; water; diethylamine; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1572518-01-4
methyl-3-amino-4-bromothieno[2,3-c]pyridine-2-carboxylate

: 1572517-04-4
3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

: 1572517-05-5
3-amino-N-(2-(4-methoxyphenyl)cyclopropyl)-4-methylthieno[2,3-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 1 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube

2.1: water; potassium hydroxide / methanol / 9 h / 50 °C / Sealed tube

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 1 h / 20 °C

4.1: Lux Cellulose-3 (OJ) column / methanol; diethylamine / Supercritical conditions

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; In tetrahydrofuran; methanol; water; diethylamine; N,N-dimethyl-formamide;