5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester

Base Information

• Chemical Name: 5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester
• CAS No.: 642442-33-9
• Molecular Formula: C₃₁H₄₄O₁₃
• Molecular Weight: 624.683
• Mol file: 642442-33-9.mol

Synonyms:5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester

Chemical Property of 5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester

There total 1 articles about 5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Dimethyl 5-hydroxyisophthalate (13036-02-7) + 3,5-bis{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzylbromide (246140-08-9) → 5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester (642442-33-9)

Guidance literature:

With 18-crown-6 ether; potassium carbonate; In acetone; for 48h; Heating;

DOI:10.1021/jo035040a

Reference yield: 88.0%

5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester (642442-33-9) → [3-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-5-hydroxymethyl-phenyl]-methanol (642442-36-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 6h;

DOI:10.1021/jo035040a

Reference yield:

5-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-isophthalic acid dimethyl ester (642442-33-9) → Malonic acid mono-[3-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-5-(2-carboxy-acetoxymethyl)-benzyl] ester

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / LiAlH₄ / tetrahydrofuran / 6 h / 0 °C

2: 100 percent / 4 h / 120 °C

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jo035040a

upstream raw materials:

Dimethyl 5-hydroxyisophthalate

3,5-bis{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}benzylbromide

Downstream raw materials:

[3-(3,5-bis-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-5-hydroxymethyl-phenyl]-methanol