(R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride

Base Information

Chemical Name:(R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride
CAS No.:1335122-89-8
Molecular Formula:C₂₁H₂₇N₅O₆*ClH
Molecular Weight:481.936
Hs Code.:

Synonyms:(R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride

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Chemical Property of (R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride

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Technology Process of (R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride

There total 6 articles about (R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1335123-04-0
C₃₁H₄₃N₅O₁₀

: 1335122-89-8
(R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 20 ℃; for 4h;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1186120-57-9
tert-butyl (1S,2R)-3-bromo-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

: 1335122-89-8
(R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

2: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

4: hydrogenchloride / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; sodium azide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.07.008

Reference yield:

: 1186120-58-0
tert-butyl(1S,2S)-3-azido-1-hydroxy-1-(4-nitrophenyl)propan-2-ylcarbamate

: 1335122-89-8
(R)-2-amino-N-((S)-1-((2S,3S)-2-amino-3-hydroxy-3-(4-nitrophenyl)propylamino)-3-hydroxy-1-oxopropan-2-yl)-3-phenylpropanamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / tetrahydrofuran; water / 24 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane

3: hydrogenchloride / ethyl acetate / 4 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1016/j.bmc.2011.07.008