(+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid

Base Information

Chemical Name:(+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid
CAS No.:1383800-69-8
Molecular Formula:C₂₇H₂₇F₃N₂O₄
Molecular Weight:500.518
Hs Code.:

Synonyms:(+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid

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Chemical Property of (+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid

Chemical Property:

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Technology Process of (+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid

There total 5 articles about (+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₉F₃N₂O₄

: 1383800-69-8
(+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid

Guidance literature:: C₂₈H₂₉F₃N₂O₄; With water; lithium hydroxide; In tetrahydrofuran; at 30 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; water; pH=5;

Reference yield:

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1383800-69-8
(+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / palladium diacetate / water / 60 h

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 30 °C

3.2: pH 5

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.25 h

4.2: 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 30 °C

5.2: pH 5

With 4-methyl-morpholine; di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; HATU; lithium hydroxide; palladium diacetate; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 106-41-2
4-bromo-phenol

: 1383800-69-8
(+/-)-3-(6-(3-methyl-1-(4'-(trifluoromethyl)biphenyl-4-yloxy)butyl)nicotinamido)propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / palladium diacetate / water / 60 h

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 30 °C

3.2: pH 5

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.25 h

4.2: 20 °C

5.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 30 °C

5.2: pH 5

With 4-methyl-morpholine; di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; HATU; lithium hydroxide; palladium diacetate; In tetrahydrofuran; water; N,N-dimethyl-formamide;