bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-4-chlorophenyl]ethynyl}deoxyribose

Base Information

• Chemical Name: bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-4-chlorophenyl]ethynyl}deoxyribose
• CAS No.: 1332828-76-8
• Molecular Formula: C₃₁H₂₅ClF₃NO₆
• Molecular Weight: 599.991
• Mol file: 1332828-76-8.mol

Synonyms:bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-4-chlorophenyl]ethynyl}deoxyribose

Chemical Property of bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-4-chlorophenyl]ethynyl}deoxyribose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

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Technology Process of bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-4-chlorophenyl]ethynyl}deoxyribose

There total 1 articles about bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-4-chlorophenyl]ethynyl}deoxyribose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-ethynyl-1,2-dideoxy-3,5-di-O-(4-toluoyl)-β-D-ribofuranose (890025-16-8) + N-(5-chloro-2-iodophenyl)-2,2,2-trifluoroacetamide (1224955-44-5) → bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-4-chlorophenyl]ethynyl}deoxyribose (1332828-76-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; In acetonitrile; at 70 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c1ob05844d

Reference yield: 42.0%

bis-(O-toluoyl)-1β-{[2-(N-trifluoroacyl)-4-chlorophenyl]ethynyl}deoxyribose (1332828-76-8) → bis-(O-toluoyl)-1β-(1H-6-chloroindol-2-yl)deoxyribose (1332828-84-8)

Guidance literature:

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium carbonate; johnphos; In acetonitrile; at 18 - 120 ℃; Inert atmosphere;

DOI:10.1039/c1ob05844d

upstream raw materials:

1-ethynyl-1,2-dideoxy-3,5-di-O-(4-toluoyl)-β-D-ribofuranose

N-(5-chloro-2-iodophenyl)-2,2,2-trifluoroacetamide

Downstream raw materials:

bis-(O-toluoyl)-1β-(1H-6-chloroindol-2-yl)deoxyribose