Cyclopropanecarboxylic acid, 2-methoxy-3-(1-methylethyl)- (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 2-methoxy-3-(1-methylethyl)- (9CI)
• CAS No.: 122775-02-4
• Molecular Formula: C₈H₁₄O₃
• Molecular Weight: 158.197
• Mol file: 122775-02-4.mol

Synonyms:Cyclopropanecarboxylic acid, 2-methoxy-3-(1-methylethyl)- (9CI)

Chemical Property of Cyclopropanecarboxylic acid, 2-methoxy-3-(1-methylethyl)- (9CI)

Chemical Property:

• PSA: 46.53000
• LogP: 0.98800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropanecarboxylic acid, 2-methoxy-3-(1-methylethyl)- (9CI)

There total 4 articles about Cyclopropanecarboxylic acid, 2-methoxy-3-(1-methylethyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-Isopropyl-3-methoxycyclopropanecarboxylic acid, methyl ester (122775-10-4) → 2-Isopropyl-3-methoxy-cyclopropanecarboxylic acid (122775-02-4,126639-20-1)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 5h;

DOI:10.1055/s-1989-27165

Reference yield:

2-bromo-3-methylbutyraldehyde dimethyl acetal (98429-74-4) → 2-Isopropyl-3-methoxy-cyclopropanecarboxylic acid (122775-02-4,126639-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 61 percent / Et₂O*BF₃ / 0.75 h / 5 °C

2: 96 percent / KOH / dimethylformamide / 7 h / 0 °C

3: 67 percent / 4 M aq. NaOH / 5 h / 20 °C

With potassium hydroxide; sodium hydroxide; boron trifluoride diethyl etherate; In N,N-dimethyl-formamide;

DOI:10.1055/s-1989-27165

Reference yield:

isovaleraldehyde (590-86-3) → 2-Isopropyl-3-methoxy-cyclopropanecarboxylic acid (122775-02-4,126639-20-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 63 percent / Br₂, molecular sieves 3 Angstroem / 3 h / Heating

2: 61 percent / Et₂O*BF₃ / 0.75 h / 5 °C

3: 96 percent / KOH / dimethylformamide / 7 h / 0 °C

4: 67 percent / 4 M aq. NaOH / 5 h / 20 °C

With potassium hydroxide; sodium hydroxide; 3 A molecular sieve; bromine; boron trifluoride diethyl etherate; In N,N-dimethyl-formamide;

DOI:10.1055/s-1989-27165

upstream raw materials:

2-Isopropyl-3-methoxycyclopropanecarboxylic acid, methyl ester

2-bromo-3-methylbutyraldehyde dimethyl acetal

4-Bromo-3-methoxy-5-methyl-hexanoic acid methyl ester

isovaleraldehyde

Refernces