3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one

Base Information

Chemical Name:3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one
CAS No.:1608152-71-1
Molecular Formula:C₃₅H₂₇NO₅
Molecular Weight:541.603
Hs Code.:

Synonyms:3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one

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Chemical Property of 3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one

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Technology Process of 3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one

There total 4 articles about 3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1608152-61-9
3-(bis(4-hydroxyphenyl)methylene)-5-iodo-1-(4 methoxybenzyl)indolin-2-one

: 89466-08-0
2-hydroxyphenyl boronic acid

: 1608152-71-1
3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 120 ℃; for 0.5h; Microwave irradiation;
DOI:10.1002/cmdc.201400003

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 1608152-71-1
3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

1.2: 5 h / 20 °C / Inert atmosphere

2.1: zinc; titanium tetrachloride; pyridine / tetrahydrofuran / Reflux

3.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; sodium hydride; potassium carbonate; zinc; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 2.1: |McMurry Reaction / 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201400003

Reference yield:

: 1034766-34-1
5-iodo-1(4-methoxybenzyl)-1H-indole-2,3-dione

: 1608152-71-1
3-(bis(4-hydroxyphenyl)methylene)-5-(2-hydroxyphenyl)-1-(4-methoxybenzyl)indolin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: zinc; titanium tetrachloride; pyridine / tetrahydrofuran / Reflux

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 120 °C / Microwave irradiation

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; titanium tetrachloride; potassium carbonate; zinc; In tetrahydrofuran; 1,4-dioxane; 1: |McMurry Reaction / 2: |Suzuki-Miyaura Coupling;
DOI:10.1002/cmdc.201400003