5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium

Base Information

Chemical Name:5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium
CAS No.:688000-87-5
Molecular Formula:C₅₂H₄₄F₉N₄O₇
Molecular Weight:1007.93
Hs Code.:

5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium

Synonyms:5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium

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Chemical Property of 5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium

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Technology Process of 5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium

There total 5 articles about 5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 407-25-0
trifluoroacetic anhydride

: 701980-20-3
3,8-diamino-5-(3-{3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propylamino}-propyl)-6-phenyl-phenanthridinium

: 688000-87-5
5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 0.333333h;
DOI:10.1002/anie.200353153

Reference yield:

: 52009-64-0
3,8-diamino-6-phenylphenanthridine

: 688000-87-5
5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / CH₂Cl₂ / 24 h / 20 °C

2: 82 percent / tetrahydrofuran / 216 h / 65 °C

3: 91 percent / (i-Pr)2NEt / dimethylformamide / 55 °C

4: 97 percent / Bu₃SnH; PPh₃ / [Pd(PPh₃)4] / CH₂Cl₂; H₂O / 1.5 h / 20 °C

5: 59 percent / pyridine / CH₂Cl₂ / 0.33 h / 0 - 20 °C

With pyridine; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.200353153

Reference yield:

: 666841-56-1
3,8-bis[(allyloxycarbonyl)amino]-6-phenylphenanthridine

: 688000-87-5
5-{3-[{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-hydroxy-propyl}-(2,2,2-trifluoro-acetyl)-amino]-propyl}-6-phenyl-3,8-bis-(2,2,2-trifluoro-acetylamino)-phenanthridinium

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / tetrahydrofuran / 216 h / 65 °C

2: 91 percent / (i-Pr)2NEt / dimethylformamide / 55 °C

3: 97 percent / Bu₃SnH; PPh₃ / [Pd(PPh₃)4] / CH₂Cl₂; H₂O / 1.5 h / 20 °C

4: 59 percent / pyridine / CH₂Cl₂ / 0.33 h / 0 - 20 °C

With pyridine; tri-n-butyl-tin hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.200353153