ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Base Information

• Chemical Name: ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate
• CAS No.: 165807-51-2
• Molecular Formula: C₁₇H₁₅N₃O₆S
• Molecular Weight: 389.389

Synonyms:ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Chemical Property of ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

There total 5 articles about ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(5-methyl-2,4-dioxo-6-phenyl-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester (165807-45-4) → ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165807-51-2)

Guidance literature:

With sodium nitrate; sulfuric acid; at 0 ℃; for 1h;

DOI:10.1248/cpb.46.1724

Reference yield: 52.0%

→ ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165807-51-2)

Guidance literature:

Reference yield:

4-bromophenyl acetone (6186-22-7) → ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate (165807-51-2)

Guidance literature:

Multi-step reaction with 4 steps

1: NH₄OAc, AcOH / benzene / 24 h / Heating

2: S, Et₂NH / ethanol / 2 h / 60 °C

3: 1.) pyridine, 2.) NaOEt / 1.) 45 deg C, 3 h, 2.) EtOH, RT, 1.5 h

4: 52 percent / conc. H₂SO₄, NaNO₃ / 1 h / 0 °C

With pyridine; sodium nitrate; sulfuric acid; ammonium acetate; sodium ethanolate; acetic acid; diethylamine; In ethanol; benzene;

DOI:10.1248/cpb.46.1724

upstream raw materials:

(5-methyl-2,4-dioxo-6-phenyl-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester

4-bromophenyl acetone

2-amino-5-(4-bromo-phenyl)-4-methyl-thiophene-3-carboxylic acid ethyl ester

Downstream raw materials:

[5-methyl-1-(2-methylsulfanyl-benzyl)-6-(4-nitro-phenyl)-2,4-dioxo-1,4-dihydro-2H-thieno[2,3-d]pyrimidin-3-yl]-acetic acid ethyl ester

ethyl 6-(4-aminophenyl)-5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

ethyl 5-methyl-1-(2-methylthiobenzyl)-2,4-dioxo-6-(4-propionylaminophenyl)-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

ethyl 2,4(1H,3H)-dioxo-1-(2-methoxybenzyl)-5-{(N-methyl-N-phenyl)aminomethyl}-6-phenylthieno[2,3-d]pyrimidine-3-acetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 165807-51-2 ethyl 5-methyl-6-(4-nitrophenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno<2,3-d>pyrimidine-3-acetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send