benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate

Base Information

Chemical Name:benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate
CAS No.:1297550-58-3
Molecular Formula:C₂₉H₂₆Cl₂F₃NO₄
Molecular Weight:580.431
Hs Code.:

Synonyms:benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate

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Chemical Property of benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate

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Technology Process of benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate

There total 12 articles about benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1297550-39-0
(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl chloride

: 1297549-13-3
benzyl [3-(3-amino-4-chlorophenyl)oxetan-3-yl]acetate

: 1297550-58-3
benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate

Guidance literature:: (2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃;

benzyl [3-(3-amino-4-chlorophenyl)oxetan-3-yl]acetate; In tetrahydrofuran; for 2h;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 835629-56-6
(3R)-4,4,4-trifluoro-3-methylbutanoic acid

: 1297550-58-3
benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 2 h / 80 °C

2.1: lithium hexamethyldisilazane / toluene / 0.17 h / -20 - -10 °C / Inert atmosphere

2.2: 4.17 h / 20 - 80 °C / Inert atmosphere

3.1: sodium hydroxide; water / 1,4-dioxane / 3 h / 50 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / -10 - -5 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

5.2: 2 h

With thionyl chloride; oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 1297549-70-2
(+)-ethyl (3R)-4,4,4-trifluoro-3-methylbutanoate

: 1297550-58-3
benzyl [3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)oxetan-3-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / toluene / 0.17 h / -20 - -10 °C / Inert atmosphere

1.2: 4.17 h / 20 - 80 °C / Inert atmosphere

2.1: sodium hydroxide; water / 1,4-dioxane / 3 h / 50 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / -10 - -5 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 °C

4.2: 2 h

With oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/acs.jmedchem.0c02154