(S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

Base Information

Chemical Name:(S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene
CAS No.:1227928-20-2
Molecular Formula:C₂₂H₂₂O₂
Molecular Weight:318.415
Hs Code.:

Synonyms:(S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

Suppliers and Price of (S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

There total 4 articles about (S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1227928-13-3
(S,S)-(+)-1,4-di(methoxycarbonyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

: 1227928-20-2
(S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

Guidance literature:: (S,S)-(+)-1,4-di(methoxycarbonyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 0.0833333h; Inert atmosphere;

With water; In tetrahydrofuran; diethyl ether; ethyl acetate; Inert atmosphere;
DOI:10.1002/anie.200907033

Reference yield:

: 1227928-08-6
(S,S)-1,4-di(methoxycarbonyl) bicyclo[2.2.2]octane-2,5-dione

: 1227928-20-2
(S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 6 h / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.08 h / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; diethyl ether; ethanol; water; toluene;
DOI:10.1039/c2cc17120a

Reference yield:

: 1227928-12-2
(S,S)-1,4-di(methoxycarbonyl)-2,5-di(trifluromethylsulfonyloxy)bicyclo[2.2.2]octa-2,5-diene

: 1227928-20-2
(S,S)-(+)-1,4-di(hydroxymethyl)-2,5-diphenylbicyclo[2.2.2]octa-2,5-diene

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / ethanol; water; toluene / 6 h / 20 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.08 h / Inert atmosphere

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; diethyl ether; ethanol; water; toluene;
DOI:10.1039/c2cc17120a