6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine

Base Information

Chemical Name:6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine
CAS No.:1398057-18-5
Molecular Formula:C₂₂H₁₅FN₆
Molecular Weight:382.4
Hs Code.:

Synonyms:6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine

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Chemical Property of 6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine

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Technology Process of 6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine

There total 5 articles about 6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 944718-17-6
3-bromo-5-(1-methyl-1H-pyrazol-4-yl)-pyridine

: 1398057-31-2
[6-(2-fluorophenyl)pyrido[2,3-b]pyrazin-8-yl]-boronic acid

: 1398057-18-5
6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine

Guidance literature:: With sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 80 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1283075-60-4
6,8-dichloropyrido[2,3-b]pyrazine

: 1398057-18-5
6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

2: bis(pinacol)diborane; potassium acetate / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 16 h / 80 °C / Inert atmosphere

3: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

With potassium acetate; sodium hydrogencarbonate; potassium hydrogencarbonate; bis(pinacol)diborane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 233770-01-9
3-bromo-5-iodopyridine

: 1398057-18-5
6-(2-fluoro-phenyl)-8-[5-(1-methyl-1H-pyrazol-4-yl)-pyridin-3-yl]-pyrido[2,3-b]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium phosphate tribasic trihydrate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

2: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 18 h / 80 °C / Inert atmosphere

With potassium phosphate tribasic trihydrate; sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;