N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide

Base Information

Chemical Name:N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide
CAS No.:121885-24-3
Molecular Formula:C₂₀H₂₁N₅O₅
Molecular Weight:411.417
Hs Code.:

Synonyms:N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide

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Chemical Property of N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide

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Technology Process of N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide

There total 8 articles about N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 121885-23-2
N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-hydroxy-ethoxy)-methyl]-9H-purin-6-yl}-benzamide

: 121885-24-3
N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(00)96433-5

Reference yield:

: 532-20-7,613-83-2,7261-25-8,7687-39-0,13221-22-2,14795-83-6,15761-67-8,20074-49-1,25545-03-3,25545-04-4,32445-75-3,34436-17-4,36441-93-7,36468-53-8,37110-85-3,37388-49-1,38029-69-5,40461-77-6,40461-89-0,41546-19-4,41546-20-7,41546-21-8,41546-26-3,41546-29-6,41546-30-9,41546-31-0,126872-16-0,131064-98-7
D-Ribose

: 121885-24-3
N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 8 steps

2: 37 percent / bis(p-nitrophenyl)phosphate / tetrahydrothiophene 1,1-dioxide / 0.75 h / 130 °C / 100 Torr

3: 58 percent / trifluoroacetic acid / tetrahydrofuran; H₂O / 21 h / 30 °C

4: sodium periodate / H₂O; methanol / 4.5 h / Ambient temperature

5: sodium borohydride / ethanol / 1 h / -20 °C

6: NaOH / methanol / 0.33 h / 0 °C

7: 85 percent / 2,2-dimethoxypropane, TsOH / 1.67 h / Ambient temperature

8: 76 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂

With sodium hydroxide; sodium tetrahydroborate; sodium periodate; oxalyl dichloride; Bis(p-nitrophenyl) phosphate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 2,2-dimethoxy-propane; trifluoroacetic acid; In tetrahydrofuran; sulfolane; methanol; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4039(00)96433-5

Reference yield:

: 114406-04-1
1,2-di-O-benzoyl-3,4-O-isopropylidene-β-D-ribopyranose

: 121885-24-3
N-{9-[(R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-(2-oxo-ethoxy)-methyl]-9H-purin-6-yl}-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: 37 percent / bis(p-nitrophenyl)phosphate / tetrahydrothiophene 1,1-dioxide / 0.75 h / 130 °C / 100 Torr

2: 58 percent / trifluoroacetic acid / tetrahydrofuran; H₂O / 21 h / 30 °C

3: sodium periodate / H₂O; methanol / 4.5 h / Ambient temperature

4: sodium borohydride / ethanol / 1 h / -20 °C

5: NaOH / methanol / 0.33 h / 0 °C

6: 85 percent / 2,2-dimethoxypropane, TsOH / 1.67 h / Ambient temperature

7: 76 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂

With sodium hydroxide; sodium tetrahydroborate; sodium periodate; oxalyl dichloride; Bis(p-nitrophenyl) phosphate; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; 2,2-dimethoxy-propane; trifluoroacetic acid; In tetrahydrofuran; sulfolane; methanol; ethanol; dichloromethane; water;
DOI:10.1016/S0040-4039(00)96433-5