7-Methoxy-4-phenyl-quinolin-2-ol

Base Information

• Chemical Name: 7-Methoxy-4-phenyl-quinolin-2-ol
• CAS No.: 30034-43-6
• Molecular Formula: C16H13 N O2
• Molecular Weight: 251.285
• Hs Code.: 2933790090
• DSSTox Substance ID: DTXSID10352305
• Nikkaji Number: J3.048.802D
• Wikidata: Q82129367
• ChEMBL ID: CHEMBL1568652
• Mol file: 30034-43-6.mol

Synonyms:7-methoxy-4-phenyl-quinolin-2-ol;30034-43-6;7-methoxy-4-phenylquinolin-2-ol;7-methoxy-4-phenyl-1H-quinolin-2-one;Enamine_000223;CBMicro_014780;7-methoxy-4-phenyl-1,2-dihydroquinolin-2-one;Oprea1_492582;Oprea1_781620;MLS000565002;SCHEMBL2798115;CHEMBL1568652;DTXSID10352305;SASFZIYJZPZALO-UHFFFAOYSA-N;7-Methoxy-4-phenyl-2-quinolinone;HMS1394K03;HMS2461M22;SMSF0005152;MFCD00843900;AKOS001027200;CB14359;SB69771;SMR000152225;BIM-0014813.P001;FT-0768585;EN300-06186;Z56757902;(R)-1-AMINO-2,2-DIMETHYLCYCLOPROPANECARBOXYLICACID

Chemical Property of 7-Methoxy-4-phenyl-quinolin-2-ol

Chemical Property:

• Vapor Pressure: 2.28E-08mmHg at 25°C
• Boiling Point: 452.2°Cat760mmHg
• Flash Point: 227.3°C
• PSA: 42.35000
• Density: 1.206g/cm³
• LogP: 3.61600
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 251.094628657
• Heavy Atom Count: 19
• Complexity: 371

Purity/Quality:

98.5% ^*data from raw suppliers

7-Methoxy-4-phenylquinolin-2-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C(=CC(=O)N2)C3=CC=CC=C3

Technology Process of 7-Methoxy-4-phenyl-quinolin-2-ol

There total 8 articles about 7-Methoxy-4-phenyl-quinolin-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

N-tosyl-3-(4-methoxyphenyl)-3-phenylacrylamide → 7-methoxy-4-phenyl-1, 2-dihydroquinolin-2-one (30034-43-6) + 4-(p-methoxyphenyl)-2-(1H)-quinolinone (37118-72-2)

Guidance literature:

With oxygen; copper diacetate; palladium dichloride; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere;

DOI:10.1021/jo100557s

Reference yield:

N-(3-methoxyphenyl)-3-oxo-3-phenylpropanamide (23058-90-4) → 7-methoxy-4-phenyl-1, 2-dihydroquinolin-2-one (30034-43-6)

Guidance literature:

With phosphoric acid; In water; at 100 ℃;

DOI:10.1016/j.tetlet.2021.153296

Reference yield:

C16H15NO2 → 7-methoxy-4-phenyl-1, 2-dihydroquinolin-2-one (30034-43-6) + 4-(p-methoxyphenyl)-2-(1H)-quinolinone (37118-72-2)

Guidance literature:

With copper(l) iodide; potassium tert-butylate; triphenylphosphine; In o-xylene; at 110 ℃; for 24h;

DOI:10.1021/jo202427m

upstream raw materials:

2-cyano-N-(3-methoxyphenyl)acetamide

phenylboronic acid

N-(3-methoxyphenyl)-3-oxo-3-phenylpropanamide

Downstream raw materials:

7-methoxy-4-phenylquinoline