4β-(prop-2-ynyloxy)epipodophyllotoxin

Base Information

• Chemical Name: 4β-(prop-2-ynyloxy)epipodophyllotoxin
• CAS No.: 1310349-59-7
• Molecular Formula: C₂₅H₂₄O₈
• Molecular Weight: 452.461
• Mol file: 1310349-59-7.mol

Synonyms:4β-(prop-2-ynyloxy)epipodophyllotoxin

Chemical Property of 4β-(prop-2-ynyloxy)epipodophyllotoxin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4β-(prop-2-ynyloxy)epipodophyllotoxin

There total 2 articles about 4β-(prop-2-ynyloxy)epipodophyllotoxin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.9%

propargyl alcohol (107-19-7) + podofilox (518-28-5) → 4β-(prop-2-ynyloxy)epipodophyllotoxin (1310349-59-7)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -20 - 0 ℃; for 2h;

DOI:10.1016/j.bmc.2012.09.009 DOI:10.1016/j.bmc.2012.09.009

Reference yield: 55.0%

propargyl alcohol (107-19-7) + podofilox (518-28-5) → 4β-(prop-2-ynyloxy)epipodophyllotoxin (1310349-59-7) + 4α-(4-O-propargyl)podophyllotoxin (1600500-11-5)

Guidance literature:

podofilox; With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 0.0833333h;

propargyl alcohol; In dichloromethane; for 1h;

DOI:10.1016/j.ejmech.2014.02.030

Reference yield: 91.0%

3-azidopropan-1-ol (72320-38-8) + 4β-(prop-2-ynyloxy)epipodophyllotoxin (1310349-59-7) → 4β-(1-hydroxypropyl-4-methyl-1,2,3-triazolyl)epipodophyllotoxin

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 50 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.5b00473

upstream raw materials:

propargyl alcohol

podofilox

Downstream raw materials:

C₃₈H₅₀N₂O₁₀S

C₂₈H₃₄N₂O₁₀S

C₂₆H₃₀N₂O₁₀S