8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

Base Information

Chemical Name:8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide
CAS No.:63176-93-2
Molecular Formula:C₁₈H₁₂ClFN₄O
Molecular Weight:354.771
Hs Code.:

Synonyms:8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

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Chemical Property of 8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

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Technology Process of 8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

There total 9 articles about 8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 109774-26-7
8-chloro-6-(2-fluorophenyl)-5,6-dihydro-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carbonitrile

: 63176-93-2
8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

Guidance literature:: With manganese(IV) oxide; In 1,2-dichloro-ethane; for 2h; Heating;
DOI:10.1002/jhet.5570230509

Reference yield:

: 59468-46-1
8?chloro-6?(2?fluorophenyl)?4H?imidazo[1,5?a][1,4]benzodiazepine?3?carboxylic acid

: 63176-93-2
8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

Guidance literature:: With ammonium hydroxide; phosphorus pentachloride; ammonia; In dichloromethane;

Reference yield:

: 109774-05-2
<7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepine-2-ylidene>-acetonitrile

: 63176-93-2
8-chloro-6-(2-chlorophenyl)-4H-imidazo<1,5-a><1,4>benzodiazepine-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / sodium nitrite, acetic acid / 0.25 h / Ambient temperature

2: 1) acetic acid, zinc dust / 1) methylene chloride, 2 h 2) ethyl acetate, reflux 5 min.

3: 88 percent / acetic acid / 0.08 h / Heating

4: 57 percent / activated manganese dioxide / 1,2-dichloro-ethane / 2 h / Heating

With manganese(IV) oxide; acetic acid; zinc; sodium nitrite; In 1,2-dichloro-ethane;
DOI:10.1002/jhet.5570230509