(4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Base Information

Chemical Name:(4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one
CAS No.:89578-78-9
Molecular Formula:C₃₄H₅₉N₃O₄SSi
Molecular Weight:634.012
Hs Code.:

(4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Synonyms:(4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Suppliers and Price of (4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

There total 22 articles about (4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 89578-77-8
<2α,6β(S*)>-N-<4-<(methylsulfonyl)oxy>butyl>-1-<3-<<(4-methylphenyl)sulfonyl>amino>propyl>-6-<2-<<(1,1-dimethylethyl)dimethylsilyl>oxy>heptyl>-1,2,3,6-tetrahydro-2-pyridineacetamide

: 89578-78-9
(4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Guidance literature:: With potassium carbonate; In acetonitrile; for 24h; Heating;
DOI:10.1021/ja00323a030

Reference yield:

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

: 89578-78-9
(4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Guidance literature:: Multi-step reaction with 7 steps

1: pyridine / CH₂Cl₂ / 0.33 h / 0 °C

2: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

3: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature

4: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 45 h

5: 82 percent / dimethylformamide / 18 h / -20 °C

6: 80 percent / Et₃N / CH₂Cl₂ / 1 h / -15 - 5 °C

7: 58 percent / K₂CO₃ / acetonitrile / 24 h / Heating

With pyridine; lithium hydroxide; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00323a030

Reference yield:

: 72952-73-9
(E)-2,4-pentadienyltrimethylsilane

: 89578-78-9
(4S,15aR)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-heptyl]-8-(toluene-4-sulfonyl)-1,4,6,7,8,9,10,11,12,13,15,15a-dodecahydro-5H-4a,8,13-triaza-benzocyclotridecen-14-one

Guidance literature:: Multi-step reaction with 18 steps

1: 69 percent / TiCl₄ / CH₂Cl₂ / -41 °C

2: 95 percent / trifluoroacetic acid / 24 h

3: 82 percent / acetone / 72 h / Heating

4: 97 percent / pyridine / 12 h

5: 83 percent / diisopropyl-ethylamine / toluene / 3 h / 215 °C

6: 96 percent / 5percent NaOH / methanol / 2 h / Ambient temperature

7: oxalyl chloride / toluene / 3 h / Ambient temperature

8: diethyl ether / 1 h / Ambient temperature

9: Ag₂O / 12 h

10: Ba(OH)2*8H₂O / various solvent(s); H₂O / 48 h / Heating

11: SOCl₂ / 12 h / Heating

12: 91 percent / 2,6-lutidine / CH₂Cl₂ / 4 h / 0 °C

13: 99 percent / diisopropylethylamine / CH₂Cl₂ / 4 h / Ambient temperature

14: 100 percent / aq. LiOH / methanol / 15 h / Ambient temperature

15: 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 45 h

16: 82 percent / dimethylformamide / 18 h / -20 °C

17: 80 percent / Et₃N / CH₂Cl₂ / 1 h / -15 - 5 °C

18: 58 percent / K₂CO₃ / acetonitrile / 24 h / Heating

With 2,6-dimethylpyridine; barium dihydroxide; lithium hydroxide; sodium hydroxide; thionyl chloride; oxalyl dichloride; N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; titanium tetrachloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; silver(l) oxide; In pyridine; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; trifluoroacetic acid;
DOI:10.1021/ja00323a030