1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Base Information

Chemical Name:1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide
CAS No.:223677-14-3
Molecular Formula:C₁₉H₂₅F₃N₂O₃
Molecular Weight:386.414
Hs Code.:

Synonyms:1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Suppliers and Price of 1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

There total 3 articles about 1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-Benzyloxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

: 223677-14-3
1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; under 3102.89 Torr;
DOI:10.1016/S0960-894X(98)00716-1

Reference yield:

: 95233-30-0
trans-4-trifluoromethylcyclohexane carboxylic acid

: 223677-14-3
1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / 0 °C

2: 1-hydroxy-7-azabenzotriazole, 1,3-dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂

3: H₂, HCl / 10 percent Pd/C / ethanol / 3102.89 Torr

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; triethylamine; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00716-1

Reference yield:

: 1-benzyloxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid

: 223677-14-3
1-Hydroxymethyl-4-trifluoromethyl-cyclohexanecarboxylic acid ((S)-1-methylcarbamoyl-2-phenyl-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-7-azabenzotriazole, 1,3-dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂

2: H₂, HCl / 10 percent Pd/C / ethanol / 3102.89 Torr

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(98)00716-1