tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

Base Information

Chemical Name:tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate
CAS No.:865253-20-9
Molecular Formula:C₃₂H₃₈N₂O₅
Molecular Weight:530.664
Hs Code.:

Synonyms:tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

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Chemical Property of tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

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Technology Process of tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

There total 4 articles about tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 479423-40-0
N-tert-butyl 4-methoxybenzylidenecarbamate

: 865253-20-9
tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

Guidance literature:: With (S)-2-(2,3-bis(dicyclohexylamino)cyclopropenimine)-3-phenylpropan-1-ol; In toluene; at 20 ℃; for 60h; Molecular sieve;

Reference yield: 74.0%

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 743430-44-6
tert-butyl 4-methoxybenzylidenecarbamate

: 865253-20-9
tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

: tert-butyl (2R,3S)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

Guidance literature:: With fluorobenzene; (S,S)-tartrate-derived diammonium salt; caesium carbonate; at -45 ℃; for 48h;
DOI:10.1002/anie.200500927

Reference yield:

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 479423-40-0
N-tert-butyl 4-methoxybenzylidenecarbamate

: 865253-20-9
tert-butyl (2S,3R)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

: tert-butyl (2R,3S)-3-((tert-butoxycarbonyl)amino)-2-((diphenylmethylene)amino)-3-(4-methoxyphenyl)propanoate

Guidance literature:: With (R)-3-(benzyloxy)-2-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)-N,N-dimethyl-N-(naphthalen-1-ylmethyl)-3,3-diphenylpropan-1-aminium bromide; caesium carbonate; In toluene; at 20 ℃; for 24h; Reagent/catalyst; Overall yield = 91 percent; stereoselective reaction; Catalytic behavior;
DOI:10.1016/j.tet.2020.131484