(1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone

Base Information

Chemical Name:(1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone
CAS No.:1349862-70-9
Molecular Formula:C₂₂H₁₉N₅O
Molecular Weight:369.426
Hs Code.:

Synonyms:(1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone

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Chemical Property of (1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone

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Technology Process of (1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone

There total 8 articles about (1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1349875-09-7
[3-(3-chloropyrazin-2-yl)azetidin-1-yl]-(1-methyl-1H-benzoimidazol-2-yl)methanone

: 98-80-6
phenylboronic acid

: 1349862-70-9
(1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 80 ℃; for 12h; Inert atmosphere;

Reference yield:

: 5805-53-8
BICA methyl ester

: 1349862-70-9
(1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 4 h / 20 °C

2.1: sodium hydroxide; water / methanol / 1 h / 50 °C

2.2: pH 2

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere

With 4-methyl-morpholine; water; sodium hydride; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 20572-01-4
1-methyl-1H-benzo[d]imidazole-2-carboxylic acid

: 1349862-70-9
(1-methyl-1H-benzoimidazol-2-yl)-[3-(3-phenylpyrazin-2-yl)azetidin-1-yl]methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 24 h / 20 °C

2: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 12 h / 80 °C / Inert atmosphere

With 4-methyl-morpholine; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; N,N-dimethyl-formamide;