7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one

Base Information

Chemical Name:7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one
CAS No.:1299466-96-8
Molecular Formula:C₂₂H₁₈F₂N₂O₃
Molecular Weight:396.393
Hs Code.:

Synonyms:7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one

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Chemical Property of 7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one

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Technology Process of 7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one

There total 5 articles about 7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1299466-97-9
2-(N'-tert-butoxycarbonyl-N'-methylhydrazino)-3-(4',5-difluoro-2'-methoxybiphenyl-4-yloxymethyl)benzoic acid methyl ester

: 1299466-96-8
7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; for 1.5h; Reflux;
DOI:10.1016/j.bmcl.2013.03.049

Reference yield:

: 1299466-87-7
2-bromo-3-(4',5'-difluoro-2'-methoxy-biphenyl-4-yloxymethyl)-benzoic acid methyl ester

: 1299466-96-8
7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; palladium diacetate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; toluene;
DOI:10.1016/j.bmcl.2013.03.049

Reference yield:

: 750585-90-1
methyl 2-bromo-3-(bromomethyl)benzoate

: 1299466-96-8
7-(4',5'-difluoro-2'-methoxybiphenyl-4-yloxymethyl)-2-methyl-1,2-dihydroindazol-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: caesium carbonate; palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate / toluene / 5 h / 110 °C / Inert atmosphere; Sealed tube

3: hydrogenchloride / water; tetrahydrofuran / 1.5 h / Reflux

With hydrogenchloride; palladium diacetate; potassium carbonate; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; water; acetone; toluene;
DOI:10.1016/j.bmcl.2013.03.049