(2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate

Base Information

Chemical Name:(2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate
CAS No.:1250954-14-3
Molecular Formula:C₂₅H₂₁BrN₂O₃
Molecular Weight:477.357
Hs Code.:

Synonyms:(2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate

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Chemical Property of (2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate

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Technology Process of (2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate

There total 4 articles about (2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 3359-49-7,23772-61-4,23782-37-8
3-benzylideneoxindole

: 139575-14-7,120672-87-9
N-(4-bromobenzylidene)glycine methyl ester

: 1250954-14-3
(2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate

Guidance literature:: With cyclopentyl methyl ether; ((1S,2S)-7-chloro-1-methyl-1,2-dihydroimidazo[1,2-a]quinolin-2-yl)diphenylmethanol; copper(II) acetate monohydrate; N-ethyl-N,N-diisopropylamine; at 20 ℃; enantioselective reaction; Molecular sieve;
DOI:10.1039/c5cc02362a

Reference yield: 91.0%

: 1-(tert-butyl) 5'-methyl (2'R,3S,4'R,5'R)-2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-1,5'-dicarboxylate

: 1250954-14-3
(2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 6h; enantioselective reaction;
DOI:10.1021/acs.orglett.6b02098

Reference yield: 91.0%

: 139575-14-7,120672-87-9
N-(4-bromobenzylidene)glycine methyl ester

: 23782-37-8
(3E)-3-benzylidene-1,3-dihydro-2H-indol-2-one

: 1250954-14-3
(2'R,3S,4'R,5'R)-methyl 2'-(4-bromophenyl)-2-oxo-4'-phenylspiro[indoline-3,3'-pyrrolidine]-5'-carboxylate

: C₂₅H₂₁BrN₂O₃

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; (R_C,S_Fc)-1-(diphenylphosphino)-2-[(1-amino)ethyl]ferrocene; triethylamine; In tetrahydrofuran; at 20 ℃; for 1h; optical yield given as %ee; enantioselective reaction;
DOI:10.1038/nchem.730