N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide

Base Information

Chemical Name:N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide
CAS No.:953030-72-3
Molecular Formula:C₂₂H₃₁N₃O
Molecular Weight:353.508
Hs Code.:

Synonyms:N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide

Suppliers and Price of N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide

There total 5 articles about N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 953030-71-2
tert-butyl 3-{(3R)-3-[benzyl(cyclopropylcarbonyl)amino]pyrrolidin-1-yl}-8-azabicyclo[3.2.1]octane-8-carboxylate

: 953030-72-3
N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide

Guidance literature:: tert-butyl 3-{(3R)-3-[benzyl(cyclopropylcarbonyl)amino]pyrrolidin-1-yl}-8-azabicyclo[3.2.1]octane-8-carboxylate; With hydrogenchloride; In diethyl ether; dichloromethane; at 20 ℃;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 197450-87-6,108963-20-8
(3R)-N,1-dibenzylpyrrolidin-3-amine

: 953030-72-3
N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: ammonium formate / palladium(II) hydroxide/carbon / ethanol / 2 h / 75 °C

3: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C

4: hydrogenchloride / diethyl ether; dichloromethane / 20 °C

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; palladium(II) hydroxide/carbon; In diethyl ether; ethanol; dichloromethane;

Reference yield:

: 952744-22-8
N-benzyl-N-[(3R)-1-benzylpyrrolidin-3-yl]cyclopropanecarboxamide

: 953030-72-3
N-[(3R)-1-(8-azabicyclo[3.2.1]oct-3-yl)pyrrolidin-3-yl]-N-benzylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium formate / palladium(II) hydroxide/carbon / ethanol / 2 h / 75 °C

2: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 3 h / 20 °C

3: hydrogenchloride / diethyl ether; dichloromethane / 20 °C

With hydrogenchloride; ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; palladium(II) hydroxide/carbon; In diethyl ether; ethanol; dichloromethane;