(+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide

Base Information

Chemical Name:(+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide
CAS No.:247118-54-3
Molecular Formula:C₂₄H₃₁NO₅
Molecular Weight:413.514
Hs Code.:

Synonyms:(+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide

Suppliers and Price of (+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of (+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide

There total 3 articles about (+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

: 247118-54-3
(+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / toluene / 3 h / Heating

2: Et₃N / tetrahydrofuran / 1 h / -10 °C

3: 1.) LDA, LiCl / 1.) THF, a) -78 deg C, 1 h, b)0 deg C, 15 min, 2.) THF, 0 deg C, 3 h

With thionyl chloride; triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; toluene;
DOI:10.1016/S0957-4166(99)00167-6

Reference yield:

: 39053-78-6
3,4,5-trimethoxyphenylacetyl chloride

: 247118-54-3
(+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 1 h / -10 °C

2: 1.) LDA, LiCl / 1.) THF, a) -78 deg C, 1 h, b)0 deg C, 15 min, 2.) THF, 0 deg C, 3 h

With triethylamine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0957-4166(99)00167-6

Reference yield:

: 106-95-6
allyl bromide

: 247118-51-0
(+)-<1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)acetamide

: 247118-54-3
(+)-<2S,1'S,2'S>-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-N-methyl-2-(3,4,5-trimethoxyphenyl)-4-pentenamide

Guidance literature:: With lithium chloride; lithium diisopropyl amide; Yield given; Multistep reaction; 1.) THF, a) -78 deg C, 1 h, b)0 deg C, 15 min, 2.) THF, 0 deg C, 3 h;
DOI:10.1016/S0957-4166(99)00167-6