4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide

Base Information

Chemical Name:4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide
CAS No.:336882-26-9
Molecular Formula:C₃₅H₄₆N₂O₄
Molecular Weight:558.761
Hs Code.:

Synonyms:4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide

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Technology Process of 4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide

There total 7 articles about 4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 68797-94-4
1-acetoxy-6-bromohexane

: 336881-91-5
4-[4-(2-hydroxyphenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N,N-dimethylbutanamide

: 336882-26-9
4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide

Guidance literature:

Reference yield:

: acetic acid 6-{2-[1-(3-dimethylcarbamoyl-3,3-diphenyl-propyl)-4-hydroxy-piperidin-4-yl]-phenoxy}-hexyl ester

: 336882-26-9
4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; methanol; at 20 ℃; for 1h;
DOI:10.1248/cpb.50.292

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 336882-26-9
4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran

2: 95 percent / H₂ / Pd(OH)2 / methanol / 6 h / 20 °C / 3040 Torr

3: 76 percent / Na₂CO₃ / dimethylformamide / 8 h / 80 °C

4: K₂CO₃ / dimethylformamide / 4 h / 40 °C

5: 1 N aq. NaOH / methanol; dioxane / 1 h / 20 °C

With sodium hydroxide; hydrogen; sodium carbonate; potassium carbonate; palladium dihydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.50.292