N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide

Base Information

Chemical Name:N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide
CAS No.:1361379-84-1
Molecular Formula:C₁₉H₁₂F₃NO₃S
Molecular Weight:391.37
Hs Code.:

Synonyms:N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide

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Chemical Property of N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide

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Technology Process of N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide

There total 3 articles about N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361380-66-6
C₁₂H₉F₂NO₂S

: 393-52-2
2-Fluorobenzoyl chloride

: 1361379-84-1
N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide

Guidance literature:: C₁₂H₉F₂NO₂S; 2-Fluorobenzoyl chloride; With N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 20 ℃; for 2h;

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;

Reference yield:

: 1345119-65-4
2-(2,2-difluoro-6-methylbenzo[d][1,3]dioxol-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1361379-84-1
N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: hydrogen / palladium(II) hydroxide

3.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 20 °C

3.2: 0.5 h / 20 °C

With hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane;

Reference yield:

: 1361380-65-5
C₁₂H₇F₂NO₄S

: 1361379-84-1
N-[5-(2,2-difluoro-6-methylbenzo[d]1,3-dioxolen-5-yl)(2-thienyl)](2-fluorophenyl)carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen / palladium(II) hydroxide

2.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 20 °C

2.2: 0.5 h / 20 °C

With hydrogen; N-ethyl-N,N-diisopropylamine; dmap; palladium(II) hydroxide; In dichloromethane;