2'-deoxy-3'-O-triphenylmethyluridine

Base Information

• Chemical Name: 2'-deoxy-3'-O-triphenylmethyluridine
• CAS No.: 1140622-61-2
• Molecular Formula: C₂₈H₂₆N₂O₅
• Molecular Weight: 470.525
• Mol file: 1140622-61-2.mol

Synonyms:2'-deoxy-3'-O-triphenylmethyluridine

Chemical Property of 2'-deoxy-3'-O-triphenylmethyluridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-deoxy-3'-O-triphenylmethyluridine

There total 3 articles about 2'-deoxy-3'-O-triphenylmethyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

O5'-trityl-2'-deoxy-uridine (14270-73-6) → 2'-deoxy-3'-O-triphenylmethyluridine (1140622-61-2) + 2'-deoxy-3',5'-bis-O-triphenylmethyluridine (1140622-58-7) + 2'-deoxyuridine (951-78-0,63844-76-8) + uracil (66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6)

Guidance literature:

With copper(II) sulfate; In xylene; for 4h; Heating;

DOI:10.1080/15257770802257846

Reference yield:

C35H30N2O6 → 2'-deoxy-3'-O-triphenylmethyluridine (1140622-61-2)

Guidance literature:

With water; lithium hydroxide; In methanol; at 20 ℃; for 5h;

DOI:10.1016/j.ejmech.2013.04.034

Reference yield:

2'-deoxyuridine (951-78-0,63844-76-8) → 2'-deoxy-3'-O-triphenylmethyluridine (1140622-61-2)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 2 h / 0 °C / Inert atmosphere

2: pyridine / 18 h / 85 °C / Inert atmosphere

3: lithium hydroxide; water / methanol / 5 h / 20 °C

With water; lithium hydroxide; In pyridine; methanol;

DOI:10.1016/j.ejmech.2013.04.034

upstream raw materials:

O^5'-trityl-2'-deoxy-uridine

2'-deoxyuridine