benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate

Base Information

• Chemical Name: benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate
• CAS No.: 945473-55-2
• Molecular Formula: C₁₈H₁₆BrN₃O₂
• Molecular Weight: 386.248
• Mol file: 945473-55-2.mol

Synonyms:benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate

Chemical Property of benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate

There total 2 articles about benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

benzyl 2-amino-2-iminomethylcarbamate hydrobromide + para-bromophenacyl bromide (99-73-0,132309-76-3) → benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate (945473-55-2)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 80 ℃; for 0.5h;

DOI:10.1021/jm0705354

Reference yield:

phenylmethyl cyanomethylcarbamate (3589-41-1) → benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate (945473-55-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 8 h / 25 °C

1.2: 72 h / 25 °C

2.1: potassium carbonate / tetrahydrofuran; water / 18 h / Reflux

With sodium methylate; potassium carbonate; In tetrahydrofuran; methanol; water;

DOI:10.1021/acschembio.9b00293

Reference yield: 100.0%

benzyl ((5-(4-bromophenyl)-1H-imidazol-2-yl)methyl)carbamate (945473-55-2) → (4-(4-bromophenyl)-1H-imidazol-2-yl)methylamine hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 100 ℃; for 4h;

DOI:10.1021/acs.jmedchem.7b01622

upstream raw materials:

para-bromophenacyl bromide

phenylmethyl cyanomethylcarbamate