5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid

Base Information

Chemical Name:5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid
CAS No.:1415481-75-2
Molecular Formula:C₂₄H₁₈ClF₂NO₆
Molecular Weight:489.86
Hs Code.:

Synonyms:5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid

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Chemical Property of 5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid

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Technology Process of 5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid

There total 7 articles about 5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415312-30-9
(2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester

: 1415481-76-3
5',6'-difluoro-biphenyl-2,3'-dicarboxylic acid 2-t-butyl ester

: 1415481-75-2
5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid

Guidance literature:: (2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester; 5',6'-difluoro-biphenyl-2,3'-dicarboxylic acid 2-t-butyl ester; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.75h;

With trifluoroacetic acid; In dichloromethane; for 0.5h;

With sodium hydroxide; In tetrahydrofuran; for 2h;

Reference yield:

: 956229-69-9
2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid tert-butyl ester

: 1244642-70-3
methyl 3-bromo-4,5-difluorobenzoate

: 1415481-75-2
5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water; methanol / 0.83 h / 110 °C / Inert atmosphere; Microwave irradiation

1.2: 2 h

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.75 h / 20 °C

2.2: 0.5 h

2.3: 2 h

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; toluene;

Reference yield:

: 80126-50-7
(R)-2'-chlorophenylalanine

: 1415481-75-2
5'-[(1R,2R)-2-carboxy-1-(2-chlorobenzyl)-2-hydroxy-ethylcarbamoyl]-2',3'-difluoro-biphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / 0 °C

1.2: 4 h / pH 8 - 9

1.3: pH 1

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / -20 °C

4.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C

5.1: hydrogenchloride / 1,4-dioxane / Reflux

5.2: 4 h / Reflux

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.75 h / 20 °C

6.2: 0.5 h

6.3: 2 h

With hydrogenchloride; lithium aluminium tetrahydride; water; benzotriazol-1-ol; sodium hydrogensulfite; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;