(3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one

Base Information Edit

Chemical Name:(3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one
CAS No.:618386-15-5
Molecular Formula:C₂₆H₂₉FN₂O₂
Molecular Weight:420.527
Hs Code.:
Mol file:618386-15-5.mol

Synonyms:(3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one Edit

Chemical Property:

Boiling Point:606.9±55.0 °C(Predicted)
Density:1.206±0.06 g/cm3(Predicted)

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one

There total 2 articles about (3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: vorapaxar

: 618386-15-5
(3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one

Guidance literature:: vorapaxar; With hydrogenchloride; water; acetic acid; at 118 ℃; for 16h;

With sodium hydrogencarbonate; pH=8;

Reference yield: 20.0%

: 618386-13-3
C₂₆H₂₆FNO₃

: 618386-15-5
(3R,3aS,4S,4aR,7R,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one

: 618386-16-6
(3R,3aS,4S,4aR,7S,8aR,9aR)-7-amino-4-[(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]-decahydro-3-methylnaphtho[2,3-c]furan-1(3H)-one

Guidance literature:: C₂₆H₂₆FNO₃; With titanium(IV) isopropylate; ammonia; In ethanol; dichloromethane; at 0 ℃; for 1h;

With titanium tetrachloride; In ethanol; dichloromethane; at 20 ℃; for 0.75h;

With sodium cyanoborohydride; In methanol; at 20 ℃;
DOI:10.1021/jm800180e