(S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione

Base Information

• Chemical Name: (S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione
• CAS No.: 1092522-44-5
• Molecular Formula: C₂₂H₁₈F₂N₂O₅S
• Molecular Weight: 460.458

Synonyms:(S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione

Chemical Property of (S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione

Chemical Property:

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Technology Process of (S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione

There total 4 articles about (S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione (1092522-55-8) + propargyl bromide (106-96-7) → (S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione (1092522-44-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; toluene; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm801107u

Reference yield: 70.0%

(S)-5-((2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl)-1-(prop-2-yn-1-yl)indoline-2,3-dione (1092522-43-4) + (S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione (1092522-55-8) → (S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione (1092522-44-5)

Guidance literature:

Reference yield: 70.0%

→ (S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(prop-2-ynyl)indoline-2,3-dione (1092522-44-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; toluene; at 20 ℃; for 2h;

upstream raw materials:

(S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

propargyl bromide

5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione

(S)-5-((2-(phenoxymethyl)pyrrolidin-1-yl)sulphonyl)-1-(prop-2-yn-1-yl)indoline-2,3-dione

Downstream raw materials:

(S)-5-(2-((2,4-difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione

C₂₄H₂₂F₂⁽¹⁸⁾FN₅O₅S

indole-2,3-dione

C₂₇H₂₈F₂⁽¹⁸⁾FN₅O₆S

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