5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione
CAS No.:285549-61-3
Molecular Formula:C₄₃H₅₈N₂O₉Si₂
Molecular Weight:803.113
Hs Code.:

5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

Synonyms:5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

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Chemical Property of 5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

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Technology Process of 5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

There total 8 articles about 5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 285549-60-2
5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3R,3aS,9aR)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

: 285549-61-3
5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: 5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3R,3aS,9aR)-3-hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione; With di(1H-imidazol-2-yl)methanethione; In acetonitrile; at 20 ℃; for 21h;

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 80 ℃; for 0.833333h; Further stages.;
DOI:10.1021/ol005797d

Reference yield:

: 4433-40-3
5-hydroxymethyl uracil

: 285549-61-3
5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 79 percent / BSA; TMSOTf / acetonitrile / 2 h / 75 °C

2.1: 93 percent / DMAP / pyridine / 3 h / 20 °C

3.1: 92 percent / Na₂CO₃ / methanol / 17 h / 20 °C

4.1: 77 percent / Py / 22 h / 20 °C

5.1: thiocarbonyldiimidazole / acetonitrile / 21 h / 20 °C

5.2: 85 percent / Bu₃SnH; AIBN / toluene / 0.83 h / 80 °C

With pyridine; benzenesulfonamide; dmap; trimethylsilyl trifluoromethanesulfonate; sodium carbonate; di(1H-imidazol-2-yl)methanethione; In pyridine; methanol; acetonitrile; 1.1: Substitution / 2.1: Substitution / 3.1: Deacetylation / 4.1: Cyclization / 5.1: Barton-McCombie reduction / 5.2: Barton-McCombie reduction;
DOI:10.1021/ol005797d

Reference yield:

: 69304-37-6
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

: 285549-61-3
5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-((2R,3aS,9aR)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / Py / 22 h / 20 °C

2.1: thiocarbonyldiimidazole / acetonitrile / 21 h / 20 °C

2.2: 85 percent / Bu₃SnH; AIBN / toluene / 0.83 h / 80 °C

With pyridine; di(1H-imidazol-2-yl)methanethione; In acetonitrile; 1.1: Cyclization / 2.1: Barton-McCombie reduction / 2.2: Barton-McCombie reduction;
DOI:10.1021/ol005797d