2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide

Base Information

• Chemical Name: 2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide
• CAS No.: 1566543-34-7
• Molecular Formula: C₂₆H₃₂F₃N₇O
• Molecular Weight: 515.582

Synonyms:2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide

Chemical Property of 2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide

There total 12 articles about 2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-(2-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide (1566543-31-4) + acetaldehyde (75-07-0,9002-91-9) → 2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide (1566543-34-7)

Guidance literature:

2-(2-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide; acetaldehyde; In ethanol; for 0.166667h;

With sodium tris(acetoxy)borohydride; In ethanol; for 3h;

Reference yield:

2-(2-iodophenyl)propanoic acid (33994-46-6) → 2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide (1566543-34-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 20 °C / Inert atmosphere

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 5 h / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

4.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide; triethylamine / 1,4-dioxane / 0.67 h / 110 °C / Inert atmosphere; Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

6.1: ethanol / 0.17 h

6.2: 3 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2-iodo-2-phenylacetic acid (615256-95-6) → 2-(2-(2-(2-((1-(1-ethylpiperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide (1566543-34-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: thionyl chloride / 2 h / 40 °C

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 5 h / 60 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h

4.1: bis-triphenylphosphine-palladium(II) chloride; Tetra(tert-butyl)phosphonium-tetrafluoroborat; copper(l) iodide; triethylamine / 1,4-dioxane / 0.67 h / 110 °C / Inert atmosphere; Microwave irradiation

5.1: trifluoroacetic acid / dichloromethane / 6 h / 0 - 20 °C

6.1: ethanol / 0.17 h

6.2: 3 h

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; triethylamine; Tetra(tert-butyl)phosphonium-tetrafluoroborat; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl 4-(4-((4-((2-(1-amino-1-oxopropan-2-yl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

tert-butyl 4-(4-((4-((2-(1-amino-1-oxopropan-2-yl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate

2-(2-(2-(2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)propanamide

acetaldehyde

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