(R,R,R,R)-N⁽¹⁾-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine

Base Information

• Chemical Name: (R,R,R,R)-N⁽¹⁾-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine
• CAS No.: 1376622-95-5
• Molecular Formula: C₂₁H₂₅NO₄
• Molecular Weight: 355.434

Synonyms:(R,R,R,R)-N⁽¹⁾-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine

Chemical Property of (R,R,R,R)-N⁽¹⁾-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine

Chemical Property:

Purity/Quality:

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Technology Process of (R,R,R,R)-N⁽¹⁾-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine

There total 5 articles about (R,R,R,R)-N⁽¹⁾-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(R,R,R,R)-N(1)-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-O-methoxymethyl-5-methylpyrrolidine (1376622-94-4) → (R,R,R,R)-N(1)-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine (1376622-95-5)

Guidance literature:

With hydrogenchloride; In methanol; at 50 ℃; for 5h;

DOI:10.1016/j.tet.2012.03.045

Reference yield:

tert-butyl (R,R,R)-2-hydroxy-3-[N-benzyl-N-(α-methyl-4'-methoxybenzyl)amino]butanoate (1376622-69-3) → (R,R,R,R)-N(1)-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine (1376622-95-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: iodine; sodium hydrogencarbonate / acetonitrile / -20 - 20 °C / Inert atmosphere

5.1: acetic acid / 24 h / 30 °C / Inert atmosphere

6.1: hydrogenchloride / methanol / 5 h / 50 °C

With hydrogenchloride; n-butyllithium; iodine; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; mineral oil; 3.2: Wittig reaction;

DOI:10.1016/j.tet.2012.03.045

Reference yield:

C21H26INO3 (1376622-93-3) → (R,R,R,R)-N(1)-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-hydroxy-5-methylpyrrolidine (1376622-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 24 h / 30 °C / Inert atmosphere

2: hydrogenchloride / methanol / 5 h / 50 °C

With hydrogenchloride; acetic acid; In methanol;

DOI:10.1016/j.tet.2012.03.045

upstream raw materials:

(R,R,R,R)-N⁽¹⁾-benzyl-2-(4'-methoxyphenyl)-3-acetoxy-4-O-methoxymethyl-5-methylpyrrolidine

tert-butyl (R,R,R)-2-hydroxy-3-[N-benzyl-N-(α-methyl-4'-methoxybenzyl)amino]butanoate

(R,R,R)-2-O-methoxymethyl-3-[N-benzyl-N-(α-methyl-4'-methoxybenzyl)amino]butanal

C₂₁H₂₆INO₃

Downstream raw materials:

(R,R,R)-1-(4'-methoxyphenyl)-2,3-dihydroxy-4-(N,N-dimethylamino)pentane

(R,R,R,R)-N⁽¹⁾-2-(4'-methoxyphenyl)-3,4-dihydroxy-5-methylpyrrolidine

C₁₉H₂₃NO₃

(R,R,R,R)-N⁽¹⁾-2-(4'-methoxyphenyl)-3,4-diacetoxy-5-methylpyrrolidine

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