1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea

Base Information

• Chemical Name: 1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea
• CAS No.: 1414551-71-5
• Molecular Formula: C₂₆H₃₁N₅O₂
• Molecular Weight: 445.564
• Mol file: 1414551-71-5.mol

Synonyms:1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea

Chemical Property of 1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea

There total 7 articles about 1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

phenyl (2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)carbamate (1414573-40-2) + (3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-amine dihydrochioride → 1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea (1414551-71-5)

Guidance literature:

With nitrostyrene; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

Cinnamoyl chloride (102-92-1,17082-09-6) → 1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea (1414551-71-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 3 h / -78 - 20 °C

2.1: trifluoroacetic acid / toluene / 3 h / 5 - 20 °C

3.1: water; lithium hydroxide; dihydrogen peroxide / tetrahydrofuran / 1.17 h / 0 °C

3.2: 0 - 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 20 °C / Reflux

4.2: 15 h / Reflux

5.1: trifluoroacetic acid / 17 h / 60 °C

6.1: nitrostyrene / dichloromethane / 2 h / 0 - 20 °C

With nitrostyrene; diphenyl phosphoryl azide; water; dihydrogen peroxide; triethylamine; trifluoroacetic acid; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-amine (89399-92-8) → 1-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)-3-(2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)urea (1414551-71-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethyl acetate / 16 h / 20 °C

2: nitrostyrene / dichloromethane / 2 h / 0 - 20 °C

With nitrostyrene; sodium hydroxide; In dichloromethane; ethyl acetate;

upstream raw materials:

Cinnamoyl chloride

2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-amine

phenyl (2-phenyl-2,4,5,6-tetrahydrocyclopenta[c]pyrazol-3-yl)carbamate

(4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone