3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Base Information

• Chemical Name: 3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester
• CAS No.: 340156-78-7
• Molecular Formula: C₂₆H₂₇NO₆S
• Molecular Weight: 481.569
• Mol file: 340156-78-7.mol

Synonyms:3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Chemical Property of 3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester

There total 2 articles about 3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-acetoxymethyl-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester (50622-67-8) + thiophenol (108-98-5) → 3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester (340156-78-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(98)00201-9

Reference yield:

benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate (50622-64-5) → 3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester (340156-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 91.7 percent / acetic acid / 16 h / 20 °C

2: p-TsOH / CH₂Cl₂ / 20 °C

With toluene-4-sulfonic acid; In dichloromethane; acetic acid;

DOI:10.1016/S0040-4020(01)00088-6

Reference yield: 83.0%

2,2,2-trichloroethyl 4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrole-2-carboxylate (206861-04-3) + 3-(2-Methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-5-phenylsulfanylmethyl-1H-pyrrole-2-carboxylic acid benzyl ester (340156-78-7) → C34H37Cl3N2O12 (206861-06-5)

Guidance literature:

With disodium hydrogenphosphate; silver trifluoromethanesulfinate; In benzene; at 20 ℃; for 6h;

DOI:10.1016/S0040-4020(01)00088-6

upstream raw materials:

5-acetoxymethyl-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester

thiophenol

benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate

Downstream raw materials:

C₃₄H₃₇Cl₃N₂O₁₂