3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione
CAS No.:1380572-71-3
Molecular Formula:C₃₃H₄₁Cl₅N₂O₈Si
Molecular Weight:799.048
Hs Code.:

3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

Synonyms:3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

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Chemical Property of 3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

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Technology Process of 3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

There total 1 articles about 3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 13154-24-0
triisopropylsilyl chloride

: 1380572-68-8
3-[(2,6-dichloro-4-methoxy-phenyl)-(2,4,6-trichloro-phenyl)-methoxymethyl]-1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 1380572-71-3
3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: In dichloromethane; for 4h;
DOI:10.1016/j.tet.2012.03.121

Reference yield: 88.0%

: 1380572-71-3
3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

: 1380572-68-8
3-[(2,6-dichloro-4-methoxy-phenyl)-(2,4,6-trichloro-phenyl)-methoxymethyl]-1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 20 ℃; for 5h; chemoselective reaction;
DOI:10.1016/j.tet.2012.03.121

Reference yield:

: 1380572-71-3
3-[((2,6-dichloro-4-methoxyphenyl)(2,4,6-trichlorophenyl)methoxy)methyl]-1-(3,4-dihydroxy-5-triisopropylsilanyloxymethyltetrahydrofuran-2-yl)-1H-pyrimidine-2,4-dione

: 1380572-74-6
C₃₀H₂₉Cl₅N₂O₈

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen fluoride / acetonitrile / 5 h / 20 °C

2: 1H-imidazole / dichloromethane / 4 h

3: N-Bromosuccinimide; boron trifluoride diethyl etherate / acetonitrile / 0.25 h / 20 °C / Darkness

4: hydrogen fluoride / acetonitrile / 5 h / 20 °C

With 1H-imidazole; N-Bromosuccinimide; boron trifluoride diethyl etherate; hydrogen fluoride; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2012.03.121