2-Propenoicacid,3-(2-benzothiazolyl)-,(E)-(9CI)

Base Information

• Chemical Name: 2-Propenoicacid,3-(2-benzothiazolyl)-,(E)-(9CI)
• CAS No.: 123530-67-6
• Molecular Formula: C₁₀H₇NO₂S
• Molecular Weight: 205.237
• Mol file: 123530-67-6.mol

Synonyms:2-Propenoicacid, 3-(2-benzothiazolyl)-, (E)-

Chemical Property of 2-Propenoicacid,3-(2-benzothiazolyl)-,(E)-(9CI)

Chemical Property:

• Vapor Pressure: 1.81E-07mmHg at 25°C
• Refractive Index: 1.754
• Boiling Point: 410.3°C at 760 mmHg
• Flash Point: 202°C
• Density: 1.446g/cm³

Purity/Quality:

98% ^*data from raw suppliers

(2E)-3-(1,3-Benzothiazol-2-yl)prop-2-enoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoicacid,3-(2-benzothiazolyl)-,(E)-(9CI)

There total 7 articles about 2-Propenoicacid,3-(2-benzothiazolyl)-,(E)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

→ (E)-3-(2-benzothiazolyl)acrylic acid (123530-67-6)

Guidance literature:

Reference yield:

(E)-3-Benzothiazol-2-yl-acrylic acid ethyl ester (53004-63-0) → (E)-3-(2-benzothiazolyl)acrylic acid (123530-67-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 90 ℃; for 0.5h; Yield given;

DOI:10.1248/cpb.37.684

Reference yield:

benzothiazole-2-carbaldehyde (6639-57-2) → (E)-3-(2-benzothiazolyl)acrylic acid (123530-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / Ambient temperature

2: 10percent NaOH / ethanol / 0.5 h / 90 °C

With sodium hydroxide; sodium hydride; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.37.684

upstream raw materials:

3-benzothiazol-2-yl-1,1,1-trichloro-propan-2-ol

methyl (E)-3-(benzo[d]thiazol-2-yl)acrylate

ethyl (E)-3-(benzo[d]thiazol-2-yl)acrylate

(E)-3-Benzothiazol-2-yl-acrylic acid ethyl ester

Downstream raw materials:

(E)-N-<4-(4-diphenylmethyl-1-piperazinyl)butyl>-3-(2-benzothiazolyl)acrylamide

Refernces

• 1、 Mitsch, Andreas,Boehm, Markus,Wissner, Pia,Sattler, Isabel,Schlitzer, Martin. "Non-thiol farnesyltransferase inhibitors: utilization of an aryl binding site by 5-arylacryloylaminobenzophenones.". . p. 2657 - 2662. Retrieved 2007/10/03.