Technology Process of N-benzyl-N-(2-ethynylphenyl)-2-oxoheptanamide
There total 3 articles about N-benzyl-N-(2-ethynylphenyl)-2-oxoheptanamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-oxoheptanoic acid;
With
Dichloromethyl methyl ether;
In
dichloromethane;
at 20 ℃;
Inert atmosphere;
2′-N-benzylaminophenylacetylene;
With
dmap; triethylamine;
In
dichloromethane;
at 0 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol501479t
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide; triethylamine / 18 h / 20 °C / Inert atmosphere
2.1: Dichloromethyl methyl ether / dichloromethane / 20 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Dichloromethyl methyl ether;
In
dichloromethane; triethylamine; N,N-dimethyl-formamide;
DOI:10.1021/ol501479t
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium cyanoborohydride; acetic acid / methanol / 22 h / 0 °C
2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide; triethylamine / 18 h / 20 °C / Inert atmosphere
3.1: Dichloromethyl methyl ether / dichloromethane / 20 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; Dichloromethyl methyl ether; sodium cyanoborohydride; acetic acid;
In
methanol; dichloromethane; triethylamine; N,N-dimethyl-formamide;
DOI:10.1021/ol501479t
