(S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile

Base Information

• Chemical Name: (S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile
• CAS No.: 870086-36-5
• Molecular Formula: C₂₂H₁₉N₃O₃
• Molecular Weight: 373.411
• Mol file: 870086-36-5.mol

Synonyms:(S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile

Chemical Property of (S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile

There total 4 articles about (S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,2,3,4-tetrahydro-1-naphthylidene malononitrile (2510-03-4) + (E)-1-methoxy-4-(2-nitrovinyl)benzene (3179-10-0,5576-97-6) → (S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile (870086-36-5)

Guidance literature:

hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; In acetone; at -40 ℃; for 30h;

DOI:10.1039/b514564c

Reference yield:

3,4-dihydronaphthalene-1(2H)-one (529-34-0) → (S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile (870086-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Al₂O₃

2: 97 percent / (DHQD)2PYR / acetone / 30 h / -40 °C

With aluminum oxide; hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; In acetone; 1: Knoevenagel condensation / 2: Michael reaction;

DOI:10.1039/b514564c

Reference yield:

1,2,3,4-tetrahydro-1-naphthylidene malononitrile (2510-03-4) + (E)-1-methoxy-4-(2-nitrovinyl)benzene (3179-10-0,5576-97-6) → 2-[2-(1-(4-methoxyphenyl)-2-nitroethyl)-3,4-dihydro-2H-naphthalen-1-ylidene]malononitrile + (S,R)-2-{2-[1-(4-methoxyphenyl)-2-nitroethyl]-3,4-dihydro-2H-naphthalen-1-ylidene}malononitrile (870086-36-5)

Guidance literature:

With hydroquinindine-2,5-diphenyl-4,6-pyrimidinediyl diether; In dichloromethane; at -40 ℃; for 70h; Further Variations:; Temperatures; reaction times; Product distribution;

DOI:10.1021/ol052283b

upstream raw materials:

1,2,3,4-tetrahydro-1-naphthylidene malononitrile

(E)-1-methoxy-4-(2-nitrovinyl)benzene

3,4-dihydronaphthalene-1(2H)-one

1-methoxy-4-(2-nitro-vinyl)-benzene