(2R,3R,5S)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid

Base Information

Chemical Name:(2R*,3R*,5S*)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R*-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid
CAS No.:107699-42-3
Molecular Formula:C₃₂H₅₃NO₆Si₂
Molecular Weight:603.947
Hs Code.:

Synonyms:(2R*,3R*,5S*)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R*-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid

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Chemical Property of (2R*,3R*,5S*)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R*-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid

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Technology Process of (2R*,3R*,5S*)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R*-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid

There total 3 articles about (2R*,3R*,5S*)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R*-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 107699-41-2
benzyl (3R*,4R*,5R*,2'S*)-5-<2',3'-di(tert-butyldimethylsilyloxy)propyl>-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

: 107699-42-3
(2R*,3R*,5S*)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R*-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 1520 Torr;

Reference yield:

: 102972-08-7
(3R*,3aR*,6S*,7aR*)-6-acetoxymethyl-3-p-methoxyphenyl-4-oxo-2-phenyl-tetrahydropyrano-<3,4-d>-isoxazolidine

: 107699-42-3
(2R*,3R*,5S*)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R*-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) aq. KOH, 2.) 18-crown-6 / 1.) dioxane, RT, overnight, 2.) DMF,

2: 90 percent / imidazole / dimethylformamide / Ambient temperature

3: 85 percent / H₂ / 10percent Pd/C / aq. ethanol / 2 h / 1520 Torr

With 1H-imidazole; potassium hydroxide; 18-crown-6 ether; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 107699-40-1
benzyl (3R*,4R*,5R*,2'S*)-5-(2',3'-dihydroxypropyl)-3-p-methoxyphenyl-2-phenylisoxazolidine-4-carboxylate

: 107699-42-3
(2R*,3R*,5S*)-3-hydroxy-5,6-di-(tertbutyldimethylsilyloxy)-2-(R*-p-methoxyphenyl-N-phentlaminomethyl)hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / imidazole / dimethylformamide / Ambient temperature

2: 85 percent / H₂ / 10percent Pd/C / aq. ethanol / 2 h / 1520 Torr

With 1H-imidazole; hydrogen; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;