2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester
CAS No.:1027172-04-8
Molecular Formula:C₂₇H₃₉N₃O₇
Molecular Weight:517.623
Hs Code.:

2-(4-<i>tert</i>-butoxycarbonylamino-butyl)-4-<i>tert</i>-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2<i>H</i>-pyrazine-1-carboxylic acid benzyl ester

Synonyms:2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

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Chemical Property of 2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

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Technology Process of 2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

There total 2 articles about 2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [(2-benzyloxycarbonylamino-6-tert-butoxycarbonylamino-hexanoyl)-(2,2-dimethoxy-ethyl)-amino]-acetic acid tert-butyl ester

: 1027172-04-8
2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

Guidance literature:: With toluene-4-sulfonic acid; In toluene; at 75 ℃; for 4h;
DOI:10.1021/jm0004345

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 1027172-04-8
2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: EDC / CH₂Cl₂ / 2 h / 20 °C

2: p-toluenesulfonic acid monohydrate / toluene / 4 h / 75 °C

With toluene-4-sulfonic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; toluene;
DOI:10.1021/jm0004345

Reference yield:

: 1027172-04-8
2-(4-tert-butoxycarbonylamino-butyl)-4-tert-butoxycarbonylmethyl-3-oxo-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester

: [4-[2-amino-3-(4-methoxy-phenyl)-propionyl]-3-(4-tert-butoxycarbonylamino-butyl)-2-oxo-piperazin-1-yl]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 2 h

2: 99 percent / EDC / CH₂Cl₂ / 1 h / 20 °C

3: H₂ / 10percent Pd/C / methanol / 0.5 h / 20 °C

With hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm0004345