N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal

Base Information

Chemical Name:N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal
CAS No.:146073-39-4
Molecular Formula:C₂₅H₃₄N₂O₆S
Molecular Weight:490.621
Hs Code.:

Synonyms:N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal

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Technology Process of N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal

There total 1 articles about N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 146073-38-3
methyl 3-oxo-4-(1-phenylsulfonyl-2-pyrrolyl)butanoate trimethylene acetal

: Lithium; 1-dipropylamino-ethenolate

: 146073-39-4
N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal

: 3-[2-(1-Benzenesulfonyl-1H-pyrrol-2-ylmethyl)-[1,3]dioxan-2-ylmethyl]-3-hydroxy-pentanedioic acid bis-dipropylamide

Guidance literature:: With potassium tert-butylate; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -80 deg C, 3 min, 2.) THF, from -80 deg C to -60 deg C, 1.5 h;
DOI:10.1248/cpb.40.2344

Reference yield: 79.0%

: 146073-39-4
N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal

: 504-63-2
trimethyleneglycol

: 146073-40-7
N,N-dipropyl-<6-(3-hydroxypropoxyl)-1-phenylsulfonyl>indole-4-acetamide

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 0.5h; Heating;
DOI:10.1248/cpb.40.2344

Reference yield:

: 146073-39-4
N,N-dipropyl-3,5-dioxo-6-(1-phenylsulfonyl-2-pyrrolyl)hexanamide 5-trimethylene acetal

: 146073-41-8
N,N-dipropyl-(6-hydroxy-1-phenylsulfonyl)indole-4-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / p-TsOH*H₂O / toluene / 0.5 h / Heating

2: 1.) oxalyl chloride, DMSO / 1.) CH₂Cl₂, -82 deg C, 3 min, 2.) CH₂Cl₂, from -82 deg C to -67 deg C, 30 min

3: Et₃N / CH₂Cl₂ / 0.03 h / Heating

With oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In dichloromethane; toluene;
DOI:10.1248/cpb.40.2344