(4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester hydrochloride

Base Information

Chemical Name:(4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester hydrochloride
CAS No.:1276540-82-9
Molecular Formula:C₁₇H₂₅FN₂O₂*ClH
Molecular Weight:344.857
Hs Code.:

Synonyms:(4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester hydrochloride

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Chemical Property of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester hydrochloride

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Technology Process of (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester hydrochloride

There total 2 articles about (4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1276540-81-8
(4-fluoro-3-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester

: 1276540-82-9
(4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester hydrochloride

Guidance literature:: (4-fluoro-3-pyridin-4-yl-benzyl)-carbamic acid tert-butyl ester; With hydrogen; acetic acid; platinum(IV) oxide; In ethyl acetate; under 2585.81 - 3102.97 Torr;

With hydrogenchloride; In diethyl ether; tert-butyl methyl ether; at 0 ℃;

Reference yield:

: 153903-23-2
(4-fluorobenzyl)carbamic acid tert-butyl ester

: 1276540-82-9
(4-fluoro-3-piperidin-4-yl-benzyl)-carbamic acid tert-butyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate; n-butyllithium / tetrahydrofuran / 1.67 h / -70 - -60 °C

1.2: -70 - -45 °C

1.3: -45 - 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 5 h / 85 °C

3.1: hydrogen; acetic acid / platinum(IV) oxide / ethyl acetate / 2585.81 - 3102.97 Torr

3.2: 0 °C

With n-butyllithium; potassium tert-butylate; hydrogen; sodium carbonate; acetic acid; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water; ethyl acetate; 2.1: Suzuki Coupling;