(S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid

Base Information

Chemical Name:(S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid
CAS No.:1471250-12-0
Molecular Formula:C₃₂H₂₇ClN₄O₃S
Molecular Weight:583.11
Hs Code.:

Synonyms:(S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid

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Chemical Property of (S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid

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Technology Process of (S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid

There total 15 articles about (S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-methyl 2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetate

: 1471250-12-0
(S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In methanol; at 50 - 100 ℃; for 1h;

Reference yield:

: 1403666-49-8
(S)-1-(2-bromo-6-methyl-4-nitrophenyl)ethane-1,2-diol

: 1471250-12-0
(S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid

Guidance literature:: Multi-step reaction with 11 steps

1.1: pyridine / dichloromethane / 5 h / 0 - 20 °C

2.1: perchloric acid / 1.5 h / 0 - 20 °C

3.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

4.1: acetic acid / 0.5 h / 20 °C

4.2: 2 h / 20 °C

5.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 110 °C / Microwave irradiation

6.1: lithium hydroxide monohydrate; water / tetrahydrofuran; ethanol / 2 h / 100 °C / Inert atmosphere

7.1: periodic acid; chromium(VI) oxide / acetonitrile; water / 1.5 h / 0 - 23 °C

8.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.5 h / 20 °C

9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 95 °C

10.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 23 - 110 °C / Sealed tube; Microwave irradiation

10.2: 41 h / 110 °C

11.1: lithium hydroxide monohydrate; water / methanol / 1 h / 50 - 100 °C

With pyridine; chromium(VI) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; lithium hydroxide monohydrate; platinum on activated charcoal; water; hydrogen; potassium carbonate; acetic acid; periodic acid; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1403666-50-1
(S)-2-(2-bromo-6-methyl-4-nitrophenyl)-2-hydroxyethyl pivalate

: 1471250-12-0
(S)-2-(2-(2-(1H-indazol-5-yl)pyridin-4-yl)-7-(4-chlorophenyl)-5-methylbenzo[d]thiazol-6-yl)-2-tert-butoxyacetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: perchloric acid / 1.5 h / 0 - 20 °C

2.1: platinum on activated charcoal; hydrogen / ethanol / 3 h / 20 °C

3.1: acetic acid / 0.5 h / 20 °C

3.2: 2 h / 20 °C

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 110 °C / Microwave irradiation

5.1: lithium hydroxide monohydrate; water / tetrahydrofuran; ethanol / 2 h / 100 °C / Inert atmosphere

6.1: periodic acid; chromium(VI) oxide / acetonitrile; water / 1.5 h / 0 - 23 °C

7.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.5 h / 20 °C

8.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 95 °C

9.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 3 h / 23 - 110 °C / Sealed tube; Microwave irradiation

9.2: 41 h / 110 °C

10.1: lithium hydroxide monohydrate; water / methanol / 1 h / 50 - 100 °C

With chromium(VI) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tert.-butylnitrite; perchloric acid; lithium hydroxide monohydrate; platinum on activated charcoal; water; hydrogen; potassium carbonate; acetic acid; periodic acid; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; acetonitrile;